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Semaglutide slows things down in the entire gut, not just the stomach

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In the first 72 weeks of the study, all doses tested led to meaningful weight loss, ranging from patients losing 7.8% of their body weight at the lowest dose to 12.4% at the highest dose, with the placebo group seeing little to no weight changes. Since the trial is double-blinded, Rasouli doesnt know if Swaney is one of the 30% of patients receiving the placebo

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This structural change compromises the medication's ability to bind effectively to GLP-1 receptors, potentially reducing therapeutic efficacy